I just got off the telephone with T-Mobile RIM Support and they are reporting a global problem with sending and receiving E-Mail on BIS and BES. No ETA for correction.
Verizon BIS is Philly Metro area. 1115 and BBM is working (at least for now). Still no email, web functionality seems to be unaffected. (ie UberTwitter is working..LOL)
I heard from a couple people with BES problems but those could have been a coincidence rather than included in this problem. But the majority of the reports I saw were concerning BIS users.